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当前位置: 首页 » 食品资讯 » 外讯导读 » 欧盟评估延长使用烟酰胺核糖氯化物作为新型食品的安全性

欧盟评估延长使用烟酰胺核糖氯化物作为新型食品的安全性

放大字体  缩小字体 时间:2021-11-15 16:16 来源:食品伙伴网 作者: 泽夕   
核心提示:2021年11月12日,据欧盟食品安全局(EFSA)消息,欧盟营养、新型食品和食物过敏源(NDA)研究小组就延长使用烟酰胺核糖氯化物(nicotinamide riboside chloride)作为新型食品的安全性发表科学意见。
   食品伙伴网讯  2021年11月12日,据欧盟食品安全局EFSA)消息,欧盟营养、新型食品和食物过敏源(NDA)研究小组就延长使用烟酰胺核糖氯化物(nicotinamide riboside chloride)作为新型食品的安全性发表科学意见。
 
  部分原文报道如下:
 
  Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of an extension of use of the novel food (NF) nicotinamide riboside chloride (NRC) pursuant to Regulation (EU) 2015/2283. The assessment addresses the use of NRC in ‘meal replacement products’ and ‘nutritional drink mixes’ at levels up to 300?mg/day for the general population, and in food for special medical purposes (FSMP) and total diet replacement for weight control (TDRWC) (as per Regulation (EU) No 609/2013) at levels up to 500?mg/day in adults. Benchmark dose modelling was carried out on data from the 90-day oral toxicity studies in rats relevant to the safety assessment. Considering the lack of tolerable upper intake level (UL) for nicotinamide in infants and the narrow margin of exposure between the estimated intake in infants and the lower confidence bound of the benchmark doses (BMDL05) estimated by the models, the Panel concludes that the safety of the NF has not been established for use in ‘meal replacement products’ and ‘nutritional drink mixes’ under the proposed conditions of use. For FSMP and TDRWC, the proposed maximum use level corresponds to an intake of 210?mg nicotinamide per day, which is below the current UL for nicotinamide of 900?mg/day for adults. The Panel considers that the NF is as safe as pure nicotinamide for use in FSMP and TDRWC. The Panel, however, notes experimental data which indicate several pathways by which intakes of nicotinamide (or its precursors), at levels that are substantially higher than the physiological requirement, might cause adverse effects. The Panel considers that further investigations are required and that a re-evaluation of the UL for nicotinamide may be warranted.
 
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日期:2021-11-15
 
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